Volume 5, Issue 2, June 2019, Page: 63-72
Preparation and Research of Hydrophilic Polyurethane Modified by Folate-Lactose
Liudmyla Kulyk, Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of National Academy of Science of Ukraine, Kyiv, Ukraine
Iryna Gladyr, Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of National Academy of Science of Ukraine, Kyiv, Ukraine
Rita Rozhnova, Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of National Academy of Science of Ukraine, Kyiv, Ukraine
Dmytro Kuliesh, Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of National Academy of Science of Ukraine, Kyiv, Ukraine
Nataliia Galatenko, Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of National Academy of Science of Ukraine, Kyiv, Ukraine
Larisa Narazhaiko, Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of National Academy of Science of Ukraine, Kyiv, Ukraine
Received: May 21, 2019;       Accepted: Jun. 26, 2019;       Published: Jul. 9, 2019
DOI: 10.11648/j.ajpst.20190502.14      View  63      Downloads  20
Abstract
The biological active polyurethane (PU) based on diisocyanate prepolymer and folate-lactose (FL) was synthesized. Physical, mechanical and thermophysical properties of polymeric films were investigated. It was found that the value of the strength at break and elongation of PU with FL are higher by 83% and 22% than the corresponding physical and mechanical properties of the PU with D-lactose. According to the obtained results, the characteristic viscosity and water absorption of PU with FL are higher by 44% and 34% for the parameters of PU containing D-lactose. It has been established that prepeared PU are single-phase. The glass transition temperature is 247 K for PU with FL and 245 K for PU with D-lactose. At the same time, FL introduction into the polymer matrix causes decreasion of the heat jump value (ΔСр) to 0,1551 J/g(°C) for PU with FL sample and 0,2911 J/g(°C) for PU with D-lactose sample. Biodegradation of synthesized materials was investigated after incubation in physiological solution (0.9% NaCl) and biological medium 199 for 180 days. According to research results, polyurethane, modified by folate-lactose, retains sufficient performance for use within 6 months in conditions close to the human body. Biological activity and biocompatibility of synthesized polyurethane modified with FL were confirmed by tissue culture and histological methods.
Keywords
Folic Acid, Polyurethane, Lactose, Folate-Lactose, Biodegradation, Biocompatibility
To cite this article
Liudmyla Kulyk, Iryna Gladyr, Rita Rozhnova, Dmytro Kuliesh, Nataliia Galatenko, Larisa Narazhaiko, Preparation and Research of Hydrophilic Polyurethane Modified by Folate-Lactose, American Journal of Polymer Science and Technology. Vol. 5, No. 2, 2019, pp. 63-72. doi: 10.11648/j.ajpst.20190502.14
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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