Review Article
Engineering Lipid Nanoparticles for Enhanced Drug Encapsulation and Release: Current Status and Future Prospective
Alebachew Molla*
Issue:
Volume 11, Issue 2, June 2025
Pages:
15-23
Received:
6 September 2025
Accepted:
17 September 2025
Published:
28 October 2025
Abstract: Lipid nanoparticles have emerged as a versatile and effective platform for drug delivery, offering significant advantages such as biocompatibility, scalability, and the ability to encapsulate diverse therapeutic agents including nucleic acids, proteins, and small-molecule drugs. This review comprehensively explores engineering strategies for enhancing drug encapsulation efficiency and achieving controlled release within LNPs. Key formulation components such as ionizable and PEGylated lipids, along with lipid matrix design, play pivotal roles in optimizing nanoparticle stability, payload capacity, and release kinetics. Advances in fabrication methods including microfluidics and solvent mixing techniques have enabled reproducible production of high-quality LNPs tailored for specific therapeutic applications. The critical role of engineered LNPs is exemplified by their success in RNA therapeutics, notably COVID-19 mRNA vaccines, and expanding applications in cancer therapy and protein delivery. The review also highlights challenges like balancing stability and drug loading, minimizing toxicity, and scaling up manufacturing, alongside emerging solutions. Future perspectives emphasize the development of novel lipid materials, hybrid nanocarriers, and integration with personalized medicine and gene editing. These advances position LNPs as a cornerstone for next-generation nanomedicine platforms aimed at safe, efficient, and targeted delivery for a broad spectrum of diseases. The aim of this review is to comprehensively examine the engineering principles and formulation strategies employed to enhance drug encapsulation efficiency and achieve controlled release in lipid nanoparticles.
Abstract: Lipid nanoparticles have emerged as a versatile and effective platform for drug delivery, offering significant advantages such as biocompatibility, scalability, and the ability to encapsulate diverse therapeutic agents including nucleic acids, proteins, and small-molecule drugs. This review comprehensively explores engineering strategies for enhanc...
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Review Article
Application of Microbial Exopolysaccharides in the Cereal Products Industry: A Review
Issue:
Volume 11, Issue 2, June 2025
Pages:
24-36
Received:
14 September 2025
Accepted:
15 October 2025
Published:
28 November 2025
DOI:
10.11648/j.ajpst.20251102.12
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Abstract: Microbial exopolysaccharides (EPS) are high-molecular-weight biopolymers synthesized by various microorganisms, including bacteria, fungi, and algae. These compounds have gained noteworthy attention due to their diverse structural characteristics and functional properties, making them valuable in multiple industries, particularly in food, pharmaceuticals, and environmental applications. This review explores the structure, classification, and biosynthetic pathways of EPS, emphasizing their critical role in improving the texture, stability, and nutritional value of food products. In the cereal industry, EPS contributes significantly to the development of fermented beverages and baked goods by enhancing viscosity, moisture retention, and overall product quality. Additionally, their prebiotic properties offer considerable health benefits, including gut microbiota modulation and immune system enhancement. Despite these advantages, industrial-scale EPS production faces challenges such as high manufacturing costs, structural complexity, and purification difficulties. However, advancements in biotechnology, including strain optimization and the use of alternative carbon sources, present promising solutions for improving EPS yield and cost-effectiveness. This review not only highlights the technological and functional potential of EPS in the cereal products industry but also discusses emerging research trends and opportunities for expanding their application. With growing consumer demand for natural, clean-label ingredients, microbial EPS has the potential to revolutionize food processing by serving as sustainable and health-promoting alternatives to synthetic additives. It is hoped that this article brings more attention to these products as they meet the current and future needs of cereal industry.
Abstract: Microbial exopolysaccharides (EPS) are high-molecular-weight biopolymers synthesized by various microorganisms, including bacteria, fungi, and algae. These compounds have gained noteworthy attention due to their diverse structural characteristics and functional properties, making them valuable in multiple industries, particularly in food, pharmaceu...
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